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Fra-1/AP-1 induces EMT in mammary epithelial cells by modulating Zeb1/2 and TGFbeta expression.
Bakiri L, Macho-Maschler S, Custic I, Niemiec J, Guío-Carrión A, Hasenfuss SC, Eger A, Müller M, Beug H, Wagner EF. Bakiri L, et al. Cell Death Differ. 2015 Feb;22(2):336-50. doi: 10.1038/cdd.2014.157. Epub 2014 Oct 10. Cell Death Differ. 2015. PMID: 25301070 Free PMC article.
The AP-1 transcription factor Fra-1 has been implicated in tumorigenesis and in tumour-associated EMT in human breast cancer. ...This unique correlation among Fos genes prompted us to assess the evolutionary conservation between Fra-1 functions in EMT …
The AP-1 transcription factor Fra-1 has been implicated in tumorigenesis and in tumour-associated EMT in human breast cancer. …
Estrogen-induced expression of Fos-related antigen 1 (FRA-1) regulates uterine stromal differentiation and remodeling.
Das A, Li Q, Laws MJ, Kaya H, Bagchi MK, Bagchi IC. Das A, et al. J Biol Chem. 2012 Jun 1;287(23):19622-30. doi: 10.1074/jbc.M111.297663. Epub 2012 Apr 18. J Biol Chem. 2012. PMID: 22514284 Free PMC article.
FRA-1 expression was localized in the differentiating uterine stromal cells surrounding the implanted embryo. Attenuation of estrogen receptor alpha (Esr1) expression by siRNA mediated silencing in primary uterine stromal cells suppressed FRA-1 express …
FRA-1 expression was localized in the differentiating uterine stromal cells surrounding the implanted embryo. Attenuation of e …
Jun signalling in the epidermis: From developmental defects to psoriasis and skin tumors.
Zenz R, Wagner EF. Zenz R, et al. Int J Biochem Cell Biol. 2006;38(7):1043-9. doi: 10.1016/j.biocel.2005.11.011. Epub 2005 Dec 20. Int J Biochem Cell Biol. 2006. PMID: 16423552 Review.
Growth factors, hormones and a variety of environmental stresses activate mitogen activated protein kinase (MAPK) cascades that enhance Jun/AP-1 activity, e.g. through phosphorylation thereby regulating cell proliferation, differentiation, transformation and/or apoptosis. Embr …
Growth factors, hormones and a variety of environmental stresses activate mitogen activated protein kinase (MAPK) cascades that enhance Jun/ …
Cell-type specific DNA-protein interactions at the tissue-type plasminogen activator promoter in human endothelial and HeLa cells in vivo and in vitro.
Arts J, Herr I, Lansink M, Angel P, Kooistra T. Arts J, et al. Nucleic Acids Res. 1997 Jan 15;25(2):311-7. doi: 10.1093/nar/25.2.311. Nucleic Acids Res. 1997. PMID: 9016559 Free PMC article.
Tissue-type plasminogen activator (t-PA) gene expression in human endothelial cells and HeLa cells is stimulated by the protein kinase C activator phorbol 12-myristate 13-acetate (PMA) at the level of transcription. ...In the endothelial cells, all Jun and Fos forms (c-Jun …
Tissue-type plasminogen activator (t-PA) gene expression in human endothelial cells and HeLa cells is stimulated by the protein kinas …
AP-1 complex is effector of Hox-induced cellular proliferation and transformation.
Krosl J, Sauvageau G. Krosl J, et al. Oncogene. 2000 Oct 26;19(45):5134-41. doi: 10.1038/sj.onc.1203897. Oncogene. 2000. PMID: 11064450
Hox gene products, initially characterized as master regulators of embryonic patterning, are also required for proper functioning of adult tissues. ...However, the underlying molecular mechanisms of Hox-associated transformation and tissue growth have yet to …
Hox gene products, initially characterized as master regulators of embryonic patterning, are also required for proper functioning of …
Elevated expression of Wnt antagonists is a common event in hepatoblastomas.
Koch A, Waha A, Hartmann W, Hrychyk A, Schüller U, Waha A, Wharton KA Jr, Fuchs SY, von Schweinitz D, Pietsch T. Koch A, et al. Clin Cancer Res. 2005 Jun 15;11(12):4295-304. doi: 10.1158/1078-0432.CCR-04-1162. Clin Cancer Res. 2005. PMID: 15958610
A high frequency of activating beta-catenin mutations in hepatoblastomas indicates that the Wnt signaling pathway plays an important role in the development of this embryonic neoplasm. Stabilization of beta-catenin leads to an increased formation of nuclear beta-catenin-T- …
A high frequency of activating beta-catenin mutations in hepatoblastomas indicates that the Wnt signaling pathway plays an important role in …
Src induces urokinase receptor gene expression and invasion/intravasation via activator protein-1/p-c-Jun in colorectal cancer.
Leupold JH, Asangani I, Maurer GD, Lengyel E, Post S, Allgayer H. Leupold JH, et al. Mol Cancer Res. 2007 May;5(5):485-96. doi: 10.1158/1541-7786.MCR-06-0211. Mol Cancer Res. 2007. PMID: 17510314
In gelshifts/chromatin immunoprecipitation, Src-transfected SW480 cells showed an increase of phospho-c-Jun, in addition to JunD and Fra-1, bound to region -190/-171. Src-transfected cells showed a significant increase in c-Jun phosphorylated at Ser(73) and also Ser …
In gelshifts/chromatin immunoprecipitation, Src-transfected SW480 cells showed an increase of phospho-c-Jun, in addition to JunD and Fra …
Expression pattern of the activating protein-1 family of transcription factors in the human placenta.
Bamberger AM, Bamberger CM, Aupers S, Milde-Langosch K, Löning T, Makrigiannakis A. Bamberger AM, et al. Mol Hum Reprod. 2004 Apr;10(4):223-8. doi: 10.1093/molehr/gah011. Epub 2004 Feb 16. Mol Hum Reprod. 2004. PMID: 14985474
The human placenta is a tissue with a unique capacity for rapid, but--as opposed to malignant tumours--tightly controlled proliferation and invasion capacity. ...In the present study, we used immunohistochemistry with specific antibodies against all members of the AP-1 fam …
The human placenta is a tissue with a unique capacity for rapid, but--as opposed to malignant tumours--tightly controlled proliferati …
Fra-1 regulates vimentin during Ha-RAS-induced epithelial mesenchymal transition in human colon carcinoma cells.
Andreolas C, Kalogeropoulou M, Voulgari A, Pintzas A. Andreolas C, et al. Int J Cancer. 2008 Apr 15;122(8):1745-56. doi: 10.1002/ijc.23309. Int J Cancer. 2008. PMID: 18098284 Free article.
We demonstrated that the AP-1 sites in vimentin promoter could be involved in this regulation. A potential role of FRA-1 was suggested in the regulation of vimentin during the Ha-RAS-induced epithelial to mesenchymal transition, in association with colon cell migrat …
We demonstrated that the AP-1 sites in vimentin promoter could be involved in this regulation. A potential role of FRA-1 was s …
The PIAS-like protein Zimp10 is essential for embryonic viability and proper vascular development.
Beliakoff J, Lee J, Ueno H, Aiyer A, Weissman IL, Barsh GS, Cardiff RD, Sun Z. Beliakoff J, et al. Mol Cell Biol. 2008 Jan;28(1):282-92. doi: 10.1128/MCB.00771-07. Epub 2007 Oct 29. Mol Cell Biol. 2008. PMID: 17967885 Free PMC article.
Microarray and quantified reverse transcription-PCR analyses showed that the expression of the Fos family member Fra-1, which is involved in extraembryonic vascular development, was reduced in yolk sac tissues of zimp10 null embryos. Using fra-1 …
Microarray and quantified reverse transcription-PCR analyses showed that the expression of the Fos family member Fra-1, which …
13 results